Alfredo Brillembourg was born in New York in 1961. He received his Bachelor of Art and Architecture in 1984 and his Master of Science in Architectural Design in 1986 from Columbia University. In 1992, he received a second architecture degree from the Central University of Venezuela and began his independent practice in architecture. In 1993 he founded Urban-Think Tank (U-TT) in Caracas, Venezuela.
Since 1994 he has been a member of the Venezuelan Architects and Engineers Association and has been a guest professor at the University José Maria Vargas, the University Simon Bolívar and the Central University of Venezuela. Starting in 2007, Brillembourg has been a guest professor at the Graduate School of Architecture and Planning, Columbia University, where he co-founded the Sustainable Living Urban Model Laboratory (S.L.U.M. Lab) with Hubert Klumpner. He has over 20 years of experience practicing architecture and urban design.
Additionally, he has lectured on architecture at conferences around the world such as GSD in Boston, AEDES in Berlin, UCV in Caracas, UMSA in Miami, Berlage in Rotterdam, FAU in Sao Paulo, and UCLA in Los Angeles. Since May 2010, Brillembourg has held the chair for Architecture and Urban Design at the Swiss Institute of Technology (Eidgenössische Technische Hochschule, ETH) Zürich in Switzerland.